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Together with our like-minded people, we will be able to save all those who need treatment.
Together with our like-minded people, we will be able to save all those who need treatment.
What is Feline Infectious Peritonitis (FIP)?
Feline infectious peritonitis (FIP) is a viral disease caused by a feline coronavirus that affects wild and domestic cats.
Feline coronavirus is very common and usually doesn't cause any serious issues, aside from mild diarrhea. But when the feline coronavirus changes to a specific strain of the coronavirus, FIP can develop. In about 10% of infected cats, the virus will multiply and mutate, resulting in an infection known as feline infectious peritonitis virus (FIPV) that spreads throughout the cat’s body. It can cause an extreme inflammatory reaction in the tissues surrounding the abdomen, kidney, brain or eyes.
Feline coronavirus is very common and usually doesn't cause any serious issues, aside from mild diarrhea. But when the feline coronavirus changes to a specific strain of the coronavirus, FIP can develop. In about 10% of infected cats, the virus will multiply and mutate, resulting in an infection known as feline infectious peritonitis virus (FIPV) that spreads throughout the cat’s body. It can cause an extreme inflammatory reaction in the tissues surrounding the abdomen, kidney, brain or eyes.
What are the clinical symptoms of FIP?
FIP is most common in young cats (particularly those under 2 years), many cases are seen in kittens around 4-12 months old. There is a small subset that present older than 10 years old.
FIP can cause many different clinical signs, depending on the parts of the body affected and how the immune system reacts.
The clinical signs depend on whether the cat has the effusive or ‘wet’ form of FIP or non-effusive or ‘dry’ form of FIP, although more often than not, there is a combination of wet and dry forms present, known as a ‘mixed wet and dry’ FIP.
Diagnosis of FIP in Cats
FIP is difficult to diagnose. Many of its symptoms could also be symptoms of other issues, and there is no single blood test available to confirm FIP. While antibody levels, or titers, to coronavirus can be measured, they cannot definitively distinguish between the harmless intestinal coronavirus and the deadly FIP coronavirus. A positive result means only that the cat has had a prior exposure to coronavirus, but not necessarily to FIPV.
FIP may be considered more likely based on the clinical features and examination findings.
FIP may be considered more likely based on the clinical features and examination findings.
| Learn more about diagnosis of FIP |
Today FIP can be cured!
Until February 2019, the disease was considered incurable and only symptomatic drugs were used to improve the quality of life in the short term. But thanks to the discovery of Dr. Nils Pederson and his team, it became possible to treat FIP in cats!
Research by a group of scientists led by Professor Nils Pedersen from the University of California at Davis showed that the nucleoside GS441524, the precursor of GS5734 (Remdesivir), is effective against feline infectious peritonitis. A drug that is effective in the treatment of certain infections in humans caused by RNA viruses (Ebola). The drug inhibits viral replication and leads to a stable remission of the disease. Currently, many veterinary professionals use GS441524 and its analogues (GS protease inhibitors) to treat cats with infectious peritonitis and achieve recovery in pets.
Research by a group of scientists led by Professor Nils Pedersen from the University of California at Davis showed that the nucleoside GS441524, the precursor of GS5734 (Remdesivir), is effective against feline infectious peritonitis. A drug that is effective in the treatment of certain infections in humans caused by RNA viruses (Ebola). The drug inhibits viral replication and leads to a stable remission of the disease. Currently, many veterinary professionals use GS441524 and its analogues (GS protease inhibitors) to treat cats with infectious peritonitis and achieve recovery in pets.
Treatment of FIP in Cats
Currently, many veterinary professionals use GS441524 and its analogues (GS protease inhibitors) to treat cats with infectious peritonitis and achieve recovery in pets. In addition to GS441524 and Remdesivir, the use of Molnuperavir for the treatment of FIP has begun, but the results of its use are not yet well studied. According to veterinary reviews, it has shown less efficacy in the treatment of neural and ocular forms of FIP than GS441524.
In addition to etiotropic treatment aimed at suppressing the mutated coronavirus causing FIP, it is necessary to use pathogenetic and symptomatic treatment in order to restore the functioning of damaged organs and normalize body processes that are destroyed by the FIP virus and to eliminate individual symptoms of the disease.
In addition to etiotropic treatment aimed at suppressing the mutated coronavirus causing FIP, it is necessary to use pathogenetic and symptomatic treatment in order to restore the functioning of damaged organs and normalize body processes that are destroyed by the FIP virus and to eliminate individual symptoms of the disease.
| Learn more about treatment of FIP |
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