Treatment of FIP in Cats
Here you will find recommendations for the treatment of FIP
How to inject GS441524 correctly?
Recommendations for use and storage of GS441524 "VIBE"
Scheme of sites for GS441524 injection.
Treatment with injectable GS441524:
To give a GS441524 injection to a cat, you must follow some strong recommendations!
The injections are given subcutaneously, which means directly under the skin. The needle of the syringe should not poke into the muscle of the cat. The injections should be given every 24 hours at the same time each day. Therefore, you should determine the most convenient time for yourself, because you will have to inject your pet for a long time at this hour. It will be better if you have a person who will fix the cat during the injection, so that it is more convenient for you and safer for the cat to give the injection. It is best to have your veterinarian do the first few injections and teach you how to do them correctly. Inject GS into the green areas you see on the injection site scheme. The GS stings upon injection but the pain is over as soon as the injection is over. Remember that GS should not get into the skin, only under the skin! Because it causes skin ulcers.
Do not dilute GS441524 with water for injection or saline! Because of the optimally selected and well-adjusted solvent formulation for GS441524, manufactured under the VIBE brand, injections of this drug are less painful than similar drugs from other brands.
The use of a 2 ml, 2.5 ml, 3 ml or 5 ml syringe is recommended, depending on the required volume of solution, and a 2.5 cm 23 gauge needle. After you have filled the syringe with GS, you must change the needle to a new one. It is important to inject with a clean needle so that the GS does not get into the skin!
Alternate injection sites according to the scheme of injection sites. Do not inject in the same place for several days in a row! To inject, pull the skin fold and insert the needle at least 2/3 of its length. Make sure the needle is subcutaneous and inject the drug. Then remove the needle. After removing the needle after injection, pinch the skin fold with your fingers for 20 seconds to prevent the GS leakage from the injection site and contact with the cat's skin. Treat the cat's skin before and after the injection with Chlorhexidine.
Important: Neurological, ocular, and mixed forms of FIP are recommended to be treated with GS441524 injectable.
Treatment with the tablet form of the drug GS441524:
Treatment with the GS441524 tablet formulation is possible in the absence of gastrointestinal disease in the cat, diarrhea and vomiting, which may prevent adequate absorption of the drug. If your veterinarian has decided to treat with GS441524 tablets, it is recommended to start therapy with GS441524 "VIBE" injectable for at least 2 weeks. Only after the improvement of the general condition of the cat and positive dynamics in the course of the disease, it is possible to start oral administration of GS441524.
Tablets GS441524 "VIBE" must be given to the pet on an empty stomach for better absorption. To do this, you need to fix the cat's head, move the lower jaw and put the tablet on the root of the tongue as deep as possible. After that, you need to stroke the cat in the neck area and she will swallow the pill. If this method of administering the drug is not possible, then you can give the tablets with food during feeding.
You need to make sure that the cat swallowed the pill!
To give a GS441524 injection to a cat, you must follow some strong recommendations!
The injections are given subcutaneously, which means directly under the skin. The needle of the syringe should not poke into the muscle of the cat. The injections should be given every 24 hours at the same time each day. Therefore, you should determine the most convenient time for yourself, because you will have to inject your pet for a long time at this hour. It will be better if you have a person who will fix the cat during the injection, so that it is more convenient for you and safer for the cat to give the injection. It is best to have your veterinarian do the first few injections and teach you how to do them correctly. Inject GS into the green areas you see on the injection site scheme. The GS stings upon injection but the pain is over as soon as the injection is over. Remember that GS should not get into the skin, only under the skin! Because it causes skin ulcers.
Do not dilute GS441524 with water for injection or saline! Because of the optimally selected and well-adjusted solvent formulation for GS441524, manufactured under the VIBE brand, injections of this drug are less painful than similar drugs from other brands.
The use of a 2 ml, 2.5 ml, 3 ml or 5 ml syringe is recommended, depending on the required volume of solution, and a 2.5 cm 23 gauge needle. After you have filled the syringe with GS, you must change the needle to a new one. It is important to inject with a clean needle so that the GS does not get into the skin!
Alternate injection sites according to the scheme of injection sites. Do not inject in the same place for several days in a row! To inject, pull the skin fold and insert the needle at least 2/3 of its length. Make sure the needle is subcutaneous and inject the drug. Then remove the needle. After removing the needle after injection, pinch the skin fold with your fingers for 20 seconds to prevent the GS leakage from the injection site and contact with the cat's skin. Treat the cat's skin before and after the injection with Chlorhexidine.
Important: Neurological, ocular, and mixed forms of FIP are recommended to be treated with GS441524 injectable.
Treatment with the tablet form of the drug GS441524:
Treatment with the GS441524 tablet formulation is possible in the absence of gastrointestinal disease in the cat, diarrhea and vomiting, which may prevent adequate absorption of the drug. If your veterinarian has decided to treat with GS441524 tablets, it is recommended to start therapy with GS441524 "VIBE" injectable for at least 2 weeks. Only after the improvement of the general condition of the cat and positive dynamics in the course of the disease, it is possible to start oral administration of GS441524.
Tablets GS441524 "VIBE" must be given to the pet on an empty stomach for better absorption. To do this, you need to fix the cat's head, move the lower jaw and put the tablet on the root of the tongue as deep as possible. After that, you need to stroke the cat in the neck area and she will swallow the pill. If this method of administering the drug is not possible, then you can give the tablets with food during feeding.
You need to make sure that the cat swallowed the pill!
Duration of treatment and doses of GS441524
Dosages of GS441524 depending on the form of FIP
In the treatment of FIP, it is very important to prescribe an adequate dose of GS, and then monitor the cat's weight and correct the doses as the pet's weight increases. After 40 days of treatment, an increase in the initial dosage by 2 mg per 1 kg of cat weight is recommended.
The duration of treatment depends on the form of FIP, the clinical condition, and the cat's response to therapy. The decision to complete treatment should be made by the veterinarian based on the cat's condition and laboratory results.
Calculation of the daily dose of injectable GS441524:
Calculation of the daily dose of tableted GS441524:
The duration of treatment depends on the form of FIP, the clinical condition, and the cat's response to therapy. The decision to complete treatment should be made by the veterinarian based on the cat's condition and laboratory results.
Calculation of the daily dose of injectable GS441524:
cat weight in kg * dosage depending on the form / concentration of the GS441524 solution = daily dose in milliliters
For example: A 1.9 kg cat with effusion FIP without ocular or neurological involvement should be given GS441524 at 8 mg/kg per day. When using GS441524 injectable at 30mg/mL, the daily dose calculation would be: 1.9*8/30=0.506mL. Therefore, 0.5 ml of GS441524 will need to be drawn into the syringe for injection.
Calculation of the daily dose of tableted GS441524:
cat weight in kg * dosage depending on the form / content of GS441524 in one tablet = daily dose per tablet
For example: A 3.1 kg cat with dry FIP without ocular or neurological involvement may be given GS441524 tablets at 13 mg/kg per day. When using a tablet preparation containing 40 mg of GS441524 in one tablet, the calculation of the daily dose will be as follows: 3.1*13/40=1.0075 tablets. Therefore, after rounding, the daily dose will be 1 tablet of GS441524.
Online minimum daily dose calculation GS441524
It is necessary to measure the pet's weight weekly to adjust the dosage
Storage of GS441524
Important: When storing a solution of GS441524 with a high concentration of the active ingredient (30 or more mg / ml) at a low temperature, precipitation of the active ingredient in the form of white flakes is possible.
When the vial is warmed to room temperature, the reverse dissolution occurs. The properties of the drug after that do not change.
But, you should not use the drug until the active substance is completely dissolved in order to avoid changing the concentration of the administered dose!
It is enough to store a vial with GS441524 solution or tablets GS441524 in a cool, dark place, do not freeze.
For storage of opened vials with GS441524, a refrigerator door is well suited, where the temperature is maintained from +5 to +10 degrees Celsius.
Unopened vials can be stored in a dark place at room temperature.
Shelf life of GS441524 solution is 2 years.
When the vial is warmed to room temperature, the reverse dissolution occurs. The properties of the drug after that do not change.
But, you should not use the drug until the active substance is completely dissolved in order to avoid changing the concentration of the administered dose!
It is enough to store a vial with GS441524 solution or tablets GS441524 in a cool, dark place, do not freeze.
For storage of opened vials with GS441524, a refrigerator door is well suited, where the temperature is maintained from +5 to +10 degrees Celsius.
Unopened vials can be stored in a dark place at room temperature.
Shelf life of GS441524 solution is 2 years.
Why do veterinarians recommend using GS441524 "VIBE" solution - 30mg/ml?
Skin ulcer on a cat after using another brand of GS441524 injectable at 17.5mg/mL
The "VIBE" brand produces GS441524 injectable at 30mg/mL, unlike other brands that offer a lower concentration of GS, which is more cost effective for the manufacturer. In particular, 17 and 20 mg have become some industry standards. For us, the priority is to ensure the maximum effectiveness of your pet's treatment, reduce the cat's suffering during injections and alleviate the financial burden that falls on the owners during the treatment of a pet.
Why is a higher concentration of GS441524 in an injectable better than a lower concentration?
GS441524 Liquid Injection is a highly acidic solution. GS441524 injectable is usually produced at a pH of 1.6-1.9, since in an acidic environment, complete and uniform dissolution of the substance GS441524, which is originally produced in powder form, is possible.
Due to the high acidity of the GS441524 solution, cats experience significant pain during drug administration and skin irritation in the later stages of FIP treatment. Sharp pain during injections causes severe excitement and stress in the animal, rarely can cause pain shock. In some cases, pain and skin lesions in the form of ulcers, burns, areas of necrosis can be so severe that further injections become almost impossible. Although these skin lesions do not pose a threat to the pet's life, they can be extremely painful, cause severe discomfort to the cat, and require local treatment and treatment of the affected surface. Therefore, injections in the affected areas are impossible until the skin is completely healed. The 30 mg/mL concentration reduced the injection volume by 33% compared to the 20 mg/mL concentration and by 43.3% compared to the 17 mg/mL concentration. With the introduction of a smaller volume of the drug, the likelihood of skin damage and the incidence of ulcers and burns is significantly reduced. The GS441524 solution concentration of 30mg/mL has become the optimal choice for treatment of cats with large body weight (5 kg and above) as they require high daily doses of GS441524 and, consequently, larger volumes of the drug.
To date, veterinary practitioners treating FIP have opted for the GS441524 30mg/mL solution, which has proven to be the most effective in reducing treatment costs.
Why is a higher concentration of GS441524 in an injectable better than a lower concentration?
GS441524 Liquid Injection is a highly acidic solution. GS441524 injectable is usually produced at a pH of 1.6-1.9, since in an acidic environment, complete and uniform dissolution of the substance GS441524, which is originally produced in powder form, is possible.
Due to the high acidity of the GS441524 solution, cats experience significant pain during drug administration and skin irritation in the later stages of FIP treatment. Sharp pain during injections causes severe excitement and stress in the animal, rarely can cause pain shock. In some cases, pain and skin lesions in the form of ulcers, burns, areas of necrosis can be so severe that further injections become almost impossible. Although these skin lesions do not pose a threat to the pet's life, they can be extremely painful, cause severe discomfort to the cat, and require local treatment and treatment of the affected surface. Therefore, injections in the affected areas are impossible until the skin is completely healed. The 30 mg/mL concentration reduced the injection volume by 33% compared to the 20 mg/mL concentration and by 43.3% compared to the 17 mg/mL concentration. With the introduction of a smaller volume of the drug, the likelihood of skin damage and the incidence of ulcers and burns is significantly reduced. The GS441524 solution concentration of 30mg/mL has become the optimal choice for treatment of cats with large body weight (5 kg and above) as they require high daily doses of GS441524 and, consequently, larger volumes of the drug.
To date, veterinary practitioners treating FIP have opted for the GS441524 30mg/mL solution, which has proven to be the most effective in reducing treatment costs.
Fight FIP together!
